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pyrimethamine chemical structure In vivo, chromosomes analyzed from the bone marrow of rats dosed with pyrimethamine showed an increased number of structural and numerical aberrations. http://goodchristiansimmons.holyfamilyschooljasper.com/2017/01/03/diabetic-retinopathy-is-a-deterioration-of-the-blood-vessels-in-the-retina-that-usually-affects-both-eyes/Pregnancy: Teratogenic Effects: Pregnancy Category C. Pyrimethamine has been shown to be teratogenic in rats when given in oral doses 7times the human dose for chemoprophylaxis of malaria or 2.5times the human dose for treatment of toxoplasmosis. At these doses in rats, there was a significant increase in abnormalities such as cleft palate, brachygnathia, oligodactyly, and microphthalmia. Pyrimethamine has also been shown to produce terata such as meningocele in hamsters and cleft palate in miniature pigs when given in oral doses 170 and 5times the human dose, respectively, for chemoprophylaxis of malaria or for treatment of toxoplasmosis. There are no adequate and well-controlled studies in pregnant women. DARAPRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Concurrent administration of folinic acid is strongly recommended when used for the treatment of toxoplasmosis during pregnancy. Nursing Mothers: Pyrimethamine is excreted in human milk.http://www.datarr.com/usefuleyedoc/2017/01/03/it-is-carried-out-under-the-supervision-of-a-specialized-ophthalmologists/

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